Fall Out Boy had intended for it to be a hiatus, not a permanent break-up, but when three out of four members are killed in mysterious murders, Patrick Stump finds himself as the last Fall Out Boy standing. Devastated, Patrick begins to question whether it's worth it to go on. But his bandmates' killers know there's no question about it.

Behind the deaths of his best friends is Silence the Noise, a magical cult with a plot to kill Rock and Roll for all time and Patrick himself is the last thing standing between them and victory. Now, Patrick is the last line of defense in the ultimate battle for music and he must summon his inner strength to fight to keep his bandmates' legacy alive, all while being hunted like prey.