日照工作的時候，我們腦部的神經細胞會產生與神經退化症狀有關連的β-amyloid (Aβ)。805Please respect copyright.ＰＥＮＡＮＡsiatIsUSLg
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在睡覺尤其是深層睡眠的時候，我們腦部的神經細胞會減少產生β-amyloid (Aβ)。同時間， β-amyloid (Aβ)會從腦脊髓液轉移到血液循環系統的靜脈，離開大腦。805Please respect copyright.ＰＥＮＡＮＡ5aGx55dnW0
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夜間工作而日照時間睡覺會否達到同樣效果，暫時未有人體確實數據可以證實。805Please respect copyright.ＰＥＮＡＮＡ8lFvHUlAiG
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（圖2）睡覺時份，位於腦脊髓液(CSF)的β-amyloid (Aβ)透過星狀細胞(astrocyte)的協助，抵達靜脈排出腦外；805Please respect copyright.ＰＥＮＡＮＡ91f5XojiO6
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另有研究指出（Ref1)，部份的麻醉藥亦能促成同等效果。805Please respect copyright.ＰＥＮＡＮＡfYa2ZtaM8W
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淋巴系統(Lymphatic System）是排除廢物的系統，基於排除Aβ需要透過星狀細胞的幫助，學術界把整套系統命名為Glympathic system，取其Glial Cell(神經膠質細胞）及Lymphatic System（淋巴系統）的結合，雖則整個機制並沒有淋巴系統的參與（Ref5)。805Please respect copyright.ＰＥＮＡＮＡ6C4JMP7daF
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年老以及神經退化症狀的患者，Glympathic system效率大幅減低，因此引致大量β-amyloid (Aβ)聚積在腦部。而大量Aβ聚積在腦部的話，亦會影響睡眠的質素，形成惡性循環(Ref6)。805Please respect copyright.ＰＥＮＡＮＡsMZ8IKJW2l
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對比年輕人士，年老者的腦部Aβ水平平均高出17%。以同等年齡作比較的話，患有神經退化症人士的腦部Aβ水平則比健康人士平均高出31%。805Please respect copyright.ＰＥＮＡＮＡv0gDOcpjwg
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（圖3）為作進一步了解睡覺與腦部Aβ水平的關係，有研究(Ref2)找來20名人士，分別嘗試進行連續31小時不准睡覺以及睡覺9小時兩種環境，繼而量度Aβ水平。805Please respect copyright.ＰＥＮＡＮＡqSTpVYtrEO
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兩種測驗環境之間，測試者平均相隔15日分別進行。結果得出，不論性別歲數，通宵一晚平均將會導致5%的Aβ上升。805Please respect copyright.ＰＥＮＡＮＡQ11R1kRP9e
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（圖4）另外，他們亦發現睡眠時數與Aβ的移除有著一定程度的正面關係。而另一研究(Ref3)找來了142名試驗者，發現睡眠質素越高的話，Aβ的移除比率亦會越大。805Please respect copyright.ＰＥＮＡＮＡarbrbqqLPx
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只不過，亦有研究指出睡眠時數少於5小時或多於11的話，認知能力會有衰退傾向，但未知與Aβ是否有關。805Please respect copyright.ＰＥＮＡＮＡmljBoEPVF9
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長遠而言，通宵會導致Aβ在腦部的聚積，增加患上神經退化症狀的機會，情況許可的話，可免就則免。805Please respect copyright.ＰＥＮＡＮＡg1th7WtiCZ
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如果想我快啲出文的話，請入去Penana網站科普專欄–薯不揀單俾一個like以及Bookmark，這對我非常之重要。805Please respect copyright.ＰＥＮＡＮＡEJKXBELYrM
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Ref1:https://advances.sciencemag.org/content/5/2/eaav5447805Please respect copyright.ＰＥＮＡＮＡvayoPGMTkX
Ref2:https://www.pnas.org/content/115/17/4483805Please respect copyright.ＰＥＮＡＮＡpaJBs4Vk3c
Ref3:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676720/805Please respect copyright.ＰＥＮＡＮＡeCuJo7xrGh
Ref4:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/805Please respect copyright.ＰＥＮＡＮＡItiSXVksIT
Ref5:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/805Please respect copyright.ＰＥＮＡＮＡ9cf0dfE1s9
Ref6:https://www.nature.com/articles/nrneurol.2013.269#ref-CR13​​​​​​​8964 copyright protection801ＰＥＮＡＮＡR353yA6zLi 維尼

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